tyrosine kinase


tyrosine kinase
Kinases that phosphorylate protein tyrosine residues. These kinases play major roles in mitogenic signalling, and can be divided into two subfamilies: receptor tyrosine kinases, that have an extracellular ligand-binding domain, a single transmembrane domain, and an intracellular tyrosine kinase domain; and nonreceptor tyrosine kinases, which are soluble, cytoplasmic kinases.

Dictionary of molecular biology. 2004.

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  • Tyrosine kinase 2 — Tyrosine kinase 2, also known as TYK2, is a human gene.cite web | title = Entrez Gene: TYK2 tyrosine kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=7297| accessdate = ] Tyk2 was the first member… …   Wikipedia

  • Tyrosine kinase — A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a tyrosine residue in a protein. Tyrosine kinases are a subgroup of the larger class of protein kinases. Phosphorylation of proteins by kinases is an important… …   Wikipedia

  • Tyrosine kinase — Récepteur Tyrosine Kinase Pour les articles homonymes, voir RTK. Les Récepteurs à activité Tyrosine Kinase (RTK) font partie de la famille des récepteurs enzymes. Ce sont tous des récepteurs transmembranaires monomérique exception faite pour l… …   Wikipédia en Français

  • tyrosine kinase — ty·ro·sine ki·nase (tiґro sēn kiґnās) protein tyrosine kinase …   Medical dictionary

  • tyrosine kinase inhibitor BIBF 1120 — A substance being studied in the treatment of some types of cancer. Tyrosine kinase inhibitor BIBF 1120 blocks enzymes needed for cells to grow, and may prevent the growth of new blood vessels needed for tumors to grow. It is a type of tyrosine… …   English dictionary of cancer terms

  • tyrosine kinase inhibitor — any of a class of antineoplastic agents that inhibit protein tyrosine kinase and interfere with the action of epidermal growth factor in cancer cells …   Medical dictionary

  • tyrosine kinase inhibitor — A drug that interferes with cell communication and growth and may prevent tumor growth. Some tyrosine kinase inhibitors are used to treat cancer …   English dictionary of cancer terms

  • tyrosine kinase phosphorylation site — Substrates of tyrosine protein kinases are generally characterized by a lysine or an arginine seven residues to the N terminal side of the phosphorylated tyrosine, and an acidic residue (Asp or Glu) three or four residues to the N terminal side… …   Dictionary of molecular biology

  • tyrosine kinase inhibitor — any one of a class of drugs that interfere with cell growth in a variety of different ways by inhibiting the action of tyrosine kinases. This family of enzymes, which occur both within cells and as components of cell membrane receptor sites, have …   The new mediacal dictionary

  • tyrosine kinase inhibitor — noun a drug used in cases of chronic myeloid leukemia • Hypernyms: ↑medicine, ↑medication, ↑medicament, ↑medicinal drug …   Useful english dictionary


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